Grant: Project Grant

Abnormal mineral deposition in the vascular tissues (vascular calcification) is a life-threatening condition that is associated with both genetic and metabolic disorders. Animal models are providing valuable information about the mechanisms of this process by identifying various regulatory factors. At present our understanding of the factors regulating different kind of vascular calcification is incomplete. In the current study, we will use animal models to examine the role of various factors regulating different kind of vascular calcification. Upon completion of this study we will propose an integrated model showing the advancement of our understanding of vascular calcification. The work may identify novel drug targets to treat vascular calcification.