Grant: Travel Awards - Institute Community Support
University of Guelph
$878.00
Understanding how motors drive the pathogenesis in host cells infected with Chlamydia trachomatis.
EF 2025-26
Résumé
In 2020, the WHO reported that Chlamydia is the second leading cause of sexually transmitted infections (STI) in the world approaching 129 million new infections annually. Canada reported Chlamydia is the most common STI infection reaching 139,386 cases in 2019 with a 26% increase since 2011. Thus, it is critical to understand the mechanisms by which Chlamydia obstructs cell division at later stages, a phenotype well linked to tumorigenesis. Using high throughput BioID screen, dynein regulators and microtubule cytoskeleton proteins were enriched during early stages of Chlamydia infections. This will be followed by biochemical and imaging approaches of top hits to dissect the molecular mechanisms driving Chlamydia inclusion positioning in cells.
Programme
Travel Awards - Institute Community Support
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
558103
Name
Omer Safia
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Travel Awards - Institute Community Support
Projecttitle
Understanding how motors drive the pathogenesis in host cells infected with Chlamydia trachomatis.
Programtype2
Undefined
Orgnameinp2
University of Guelph
Cihramount2
$878
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Cellular Cytoskeleton; Chlamydia Trachomatis Infections; Dynein Motors; Dynein Regulators; High Throughput Bioid Screen; Microtubule
Abstract
In 2020, the WHO reported that Chlamydia is the second leading cause of sexually transmitted infections (STI) in the world approaching 129 million new infections annually. Canada reported Chlamydia is the most common STI infection reaching 139,386 cases in 2019 with a 26% increase since 2011. Thus, it is critical to understand the mechanisms by which Chlamydia obstructs cell division at later stages, a phenotype well linked to tumorigenesis. Using high throughput BioID screen, dynein regulators and microtubule cytoskeleton proteins were enriched during early stages of Chlamydia infections. This will be followed by biochemical and imaging approaches of top hits to dissect the molecular mechanisms driving Chlamydia inclusion positioning in cells.
Competitiondate
202511
Approvedterm2
1 yr 0 mth
Pinamesdelim
Omer, Safia
Approvedterm
1 an 0 mois
Cihrcontribution2
MI #3~ $878~ $0~
