Grant: Operating Grant
Ottawa Hospital Research Institute
$864,835.00
Interrogation of neuron-mediated morphogen signaling in the nervous system
EF 2008-09
Résumé
The Sonic hedgehog protein plays a critical role in the development of the brain and altered Sonic hedgehog signaling is associated with brain malformations and cancer in humans. Neurons represent an important source of this protein in the developing and adult brain, and the goal of this study is to understand how unique characteristics of neurons, including long distance transport of proteins in axons and electrical activity, regulate the secretion of this protein. Findings from these studies have the potential to enhance our understanding of normal development, disease and regeneration in the brain.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Other
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
178932
Name
Wallace Valerie A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Interrogation of neuron-mediated morphogen signaling in the nervous system
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$864,835
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Biochemistry; Cell Biology; Live Imaging Microscopy; Mouse Models; Primary Neuron Culture; Transfection
Abstract
The Sonic hedgehog protein plays a critical role in the development of the brain and altered Sonic hedgehog signaling is associated with brain malformations and cancer in humans. Neurons represent an important source of this protein in the developing and adult brain, and the goal of this study is to understand how unique characteristics of neurons, including long distance transport of proteins in axons and electrical activity, regulate the secretion of this protein. Findings from these studies have the potential to enhance our understanding of normal development, disease and regeneration in the brain.
Competitiondate
200903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Wallace, Valerie A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $864,835~ $0~
