Grant: Discovery Grants Program - Individual
Toronto Metropolitan University
$28,000.00
Interaction of ultrasound cavitation with membranes: Theoretical modelling and experimental characterization
EF 2023-24
Résumé
Cavitation is present in many physical phenomena and applications: Medical ultrasound imaging; disease targeted drug delivery; blood-brain-barrier opening; high intensity focused ultrasound; and sonothrombolysis. The application of ultrasound-microbubbles as a novel targeted drug delivery strategy has shown promising potential through enhanced permeability and endocytosis. In our research program, we study the phenomenon of cavitation induced through ultrasonically-stimulated bubbles and their interaction with biological membranes such as cell membranes through theoretical and experimental approaches.
Programme
Discovery Grants Program - Individual
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
RGPIN-2020-04729
Name nom
Karshafian, Raffi
Department département
Physics - Physics
Organization id
43
Institution établissement
Toronto Metropolitan University
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2023
Competition year année de concours
2020
Award amount
28000
Program id
RGPIN
Program name en
Discovery Grants Program - Individual
Program name fr
Programme de subventions à la découverte - individuelles
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
1505
Committee name en
Physics
Committee name fr
Physique
Area of application code
1102
Area of application group en
Health, education and social services
Area of application group fr
Santé publique, éducation et services sociaux
Area of application en
Biomedical engineering
Area of application fr
Génie biomédical
Research subject code
3114
Research subject group en
Physics
Research subject group fr
Biological and Medical Physics
Research subject en
Physique
Research subject fr
Physique biologique et médicale
Application title
Interaction of ultrasound cavitation with membranes: Theoretical modelling and experimental characterization
Keyword
Bacteria; Bioeffects; Bubble; Cavitation; Mammalian cell; membrane; Ultrasound
Application summary
Cavitation is present in many physical phenomena and applications: Medical ultrasound imaging; disease targeted drug delivery; blood-brain-barrier opening; high intensity focused ultrasound; and sonothrombolysis. The application of ultrasound-microbubbles as a novel targeted drug delivery strategy has shown promising potential through enhanced permeability and endocytosis. In our research program, we study the phenomenon of cavitation induced through ultrasonically-stimulated bubbles and their interaction with biological membranes such as cell membranes through theoretical and experimental approaches.
