Grant: Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Université Laval
$165,000.00
Development of an AAV library
EF 2021-22 · 2022-03-29
Résumé
There are about 7,000 different hereditary diseases each due to the mutation of a gene. These genes are expressed in different cells. The treatment of these diseases requires the delivery of a normal gene or of gene modifying agents to the appropriate cells, i.e. those involved in the disease. Adeno-associated virus (AAV) is currently the most commonly used virus for the delivery of these components. However, delivery by AAVs is not sufficiently effective and specific for effective treatment of many hereditary diseases. Thus, the objective of this project is to modify the AAVs to produce some variants, which are more specific and more effective. The team’s approach is to modify the proteins, which are at the surface of the AAVs to change their binding to the proteins, sugar and lipids at the surface of target cells. This project will generate new AAV variants able to infect more effectively various types of cells to improve the efficacy of gene therapy
Ministère
Programme
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Bénéficiaire
Emplacement
Quebec|Québec, Quebec, Canada
Type de bénéficiaire
Academia
Numéro d'entreprise
119278950
Type
Grant
Source
Proactive Disclosure - Grants and Contributions
Modifications
Chaque version de l'entente telle que publiée, de la plus ancienne à la plus récente, avec son total à cette version. Le montant ci-dessus est le plus récent.
| Modification | Date | Exercice financier | Total |
|---|---|---|---|
| 0 | 2022-03-29 | 2021-22 | $165,000.00 |
| 1 | 2022-03-29 | 2021-22 | $165,000.00 |
Tel que publié
Additional Information
This agreement has been amended 1 time(s). The end date of this agreement has been modified by 182 days.
Additional Information (French)
Cet accord a été modifié 1 fois. La date de fin du présent accord a été changé de 182 jours.
Agreement End Date
2024-09-30
Agreement Number
988603
Agreement Start Date
2022-03-29
Agreement Title
Development of an AAV library
Agreement Title (French)
Développement d’une bibliothèque de virus associés aux adénovirus
Agreement Type
Grant
Agreement Value
$165,000.00
Amendment Date
2024-02-16
Amendment Number
1
Description
There are about 7,000 different hereditary diseases each due to the mutation of a gene. These genes are expressed in different cells. The treatment of these diseases requires the delivery of a normal gene or of gene modifying agents to the appropriate cells, i.e. those involved in the disease. Adeno-associated virus (AAV) is currently the most commonly used virus for the delivery of these components. However, delivery by AAVs is not sufficiently effective and specific for effective treatment of many hereditary diseases. Thus, the objective of this project is to modify the AAVs to produce some variants, which are more specific and more effective. The team’s approach is to modify the proteins, which are at the surface of the AAVs to change their binding to the proteins, sugar and lipids at the surface of target cells. This project will generate new AAV variants able to infect more effectively various types of cells to improve the efficacy of gene therapy
Description (French)
Développement d’une bibliothèque de virus associés aux adénovirus
Expected Results
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Expected Results (French)
À court terme, les résultats prévus seront des collaborations renforcées entre l'industrie, le milieu universitaire et le gouvernement pour soutenir l'excellence en recherche. À moyen terme, les résultats attendus seront le développement de nouvelles technologies potentiellement perturbatrices avec des collaborateurs. À long terme, trouver des solutions collaboratives aux défis des politiques publiques et créer des systèmes d'innovation plus solides.
Federal Riding
Louis-Hébert
Federal Riding (French)
Louis-Hébert
Federal Riding Number
24044
NAICS Code
541710 - R&D in the physical, engineering and life sciences
Organization Code
nrc-cnrc
Organization
National Research Council Canada | Conseil national de recherches Canada
Program Name
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Name (French)
Programme de collaboration en science, en technologie et en innovation - Initiatives de collaboration en R-D
Program Purpose
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
Program Purpose (French)
Collaborer à des programmes multipartites de recherche-développement dans le but de profiter de la synergie entre la recherche transformatrice à haut risque et à haut rendement et le potentiel de découvertes scientifiques et de percées technologiques révolutionnaires dans des secteurs d’intervention prioritaires.
Recipient Business Number
119278950
Recipient City
Quebec|Québec
Recipient Country
CA
Recipient Legal Name
Université Laval
Recipient Postal Code
G1V 0A6
Recipient Province or Territory
QC
Recipient Type
S
Reference Number
172-2021-2022-Q4-988603
