Grant: Operating Grant

In order to understand how human beings work under the hood we need to understand how all of our parts work. While the genome sequence has been described as a blueprint, it is really more like a self-extracting computer program: all of the information needed to decode the message is contained in the message. What we need now is to understand how the parts encoded by the genome interpret the genome. Human genes make RNA and most go on to make proteins. Hundreds of human proteins bind RNA and regulate when it is made and what it does. The purpose of this project is to catalogue the RNA-binding preferences (e.g. preferred sequences) for all human RNA-binding proteins.