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Grant: Collaborative Research and Development Grants

University of Alberta

$177,000.00

Identifying functional gene variants and non-additive effects to enhance the power of genomic selection of purebred pigs for crossbred performance

EF 2016-17

Résumé
Genetically improving lean meat yield and pork quality is a key approach for the Canadian swine industry to enhance global competitiveness and overall profitability. Genomically enhanced estimated breeding values (GEBVs) are based on DNA marker genotypes and effects. GEBVs are used to increase the rate of genetic improvement for production traits, particularly for those that are difficult and/or expensive to measure, such as carcass yield and pork quality. The overall goal of this project is to improve the GEBVs for these traits through the integration of functional gene variants and better estimates of the overall genetic effect (additive and non-additive elements) by generating and using whole genomic sequence information and low density SNP panels. This work, a collaboration with a major Canadian and international pig breeding company will develop advanced knowledge and technology, which will benefit both the academic and industry partners. With this project, reduced genotyping cost (due to imputation) and enhanced power of genome prediction will significantly increase the adoption of genomic technologies in the Canadian swine industry. The delivery of novel genomic tools and techniques (e.g. sequence imputation, mating allocation), and experienced geneticists will improve Canadian pig breeding and selection programs . In addition, a large set of genomic data resources will be generated and shared, which represent valuable information for future genomic research in pigs. Knowledge of functional gene variants will also lead to new insights for the genomic architecture and underlying biology impacting pork yield and quality, and ultimately result in increased returns to the economic benefit of the swine industry.
Programme
Collaborative Research and Development Grants
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data

Tel que publié

Application id
485526-2015
Name nom
Plastow, Graham
Department département
Agricultural, Life and Environmental Sciences, Faculty of
Organization id
9
Institution établissement
University of Alberta
Province en
Alberta
Province fr
Alberta
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2016
Competition year année de concours
2015
Award amount
177000
Program id
CRDPJ
Program name en
Collaborative Research and Development Grants
Program name fr
Subventions de recherche et développement coopérative
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
96
Committee name en
RPP Internal Decision Cttee
Committee name fr
Cté de décision interne - PPR
Area of application code
101
Area of application group en
Agriculture and primary food production
Area of application group fr
Agriculture et produits alimentaires primaires
Area of application en
Animal production and animal primary products
Area of application fr
Production animale et produits animaux primaires
Research subject code
5004
Research subject group en
Genetics
Research subject group fr
Génétique
Research subject en
Genome analysis
Research subject fr
Analyse du génome
Partie
1
Nb partie
3
Application title
Identifying functional gene variants and non-additive effects to enhance the power of genomic selection of purebred pigs for crossbred performance
Keyword
NSERC
Application summary
Genetically improving lean meat yield and pork quality is a key approach for the Canadian swine industry to enhance global competitiveness and overall profitability. Genomically enhanced estimated breeding values (GEBVs) are based on DNA marker genotypes and effects. GEBVs are used to increase the rate of genetic improvement for production traits, particularly for those that are difficult and/or expensive to measure, such as carcass yield and pork quality. The overall goal of this project is to improve the GEBVs for these traits through the integration of functional gene variants and better estimates of the overall genetic effect (additive and non-additive elements) by generating and using whole genomic sequence information and low density SNP panels. This work, a collaboration with a major Canadian and international pig breeding company will develop advanced knowledge and technology, which will benefit both the academic and industry partners. With this project, reduced genotyping cost (due to imputation) and enhanced power of genome prediction will significantly increase the adoption of genomic technologies in the Canadian swine industry. The delivery of novel genomic tools and techniques (e.g. sequence imputation, mating allocation), and experienced geneticists will improve Canadian pig breeding and selection programs . In addition, a large set of genomic data resources will be generated and shared, which represent valuable information for future genomic research in pigs. Knowledge of functional gene variants will also lead to new insights for the genomic architecture and underlying biology impacting pork yield and quality, and ultimately result in increased returns to the economic benefit of the swine industry.