Grant: Operating Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$658,015.00
The role of mutated GABAA receptors in the pathogenesis of idiopathic generalized epilepsy
EF 2008-09
Résumé
Epilepsy is a common neurological disease affecting approximately 300 000 Canadians. Almost half of the new cases are children. With the anti-epileptic drugs that are currently available, up to 30% of individuals with epilepsy still have uncontrolled seizures. For many others, the medication will achieve control of the seizures, but with significant side-effects, impairing their quality of life. The objective of the proposed work is to identify genes that predispose to epilepsy, and to determine how mutations in these genes lead to the disease. The identification of these genes will allow a better understanding of epilepsy, and will eventually facilitate the design of more specifically targeted drugs to treat this chronic and disabling disease.
Programme
Operating Grant
Emplacement
Quebec, Canada
Type de bénéficiaire
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
180527
Name
Cossette Patrick
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Systems & Circuits Neurosciences - A
Projecttitle
The role of mutated GABAA receptors in the pathogenesis of idiopathic generalized epilepsy
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$658,015
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Electrophysiology; Epilepsy; Genetics; Immunocytochemistry; Molecular Biology; Site-Directed Mutagenesis
Abstract
Epilepsy is a common neurological disease affecting approximately 300 000 Canadians. Almost half of the new cases are children. With the anti-epileptic drugs that are currently available, up to 30% of individuals with epilepsy still have uncontrolled seizures. For many others, the medication will achieve control of the seizures, but with significant side-effects, impairing their quality of life. The objective of the proposed work is to identify genes that predispose to epilepsy, and to determine how mutations in these genes lead to the disease. The identification of these genes will allow a better understanding of epilepsy, and will eventually facilitate the design of more specifically targeted drugs to treat this chronic and disabling disease.
Competitiondate
200903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Cossette, Patrick
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $658,015~ $0~
