Grant: Travel Awards - Institute Community Support
Université Laval
$1,000.00
Associations between plasma PCSK9 levels and postprandial lipemia markers in abdominally obese men with dyslipidemia undergoing lifestyle modification therapy
EF 2017-18
Résumé
High LDL cholesterol levels is an important cardiovascular disease (CVD) risk factor. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been identified as a crucial LDL cholesterol level regulator. However, mechanisms regulating PCSK9 remain unclear specifically after meals in the post-prandial state. Lifestyle modification programs are the cornerstone of CVD management. We have measured PCSK9 levels, during a high fat meal and every 2h for 8h, in men with abdominal obesity and dyslipidemia before and after a 1-year lifestyle modification program. PCSK9 levels decreased during a high fat meal before and after the lifestyle intervention. After the 1 year lifestyle intervention PCSK9 levels were reduced at each time point of the high fat meal. The positive impact of a healthy lifestyle on CVD risk could be through PCSK9 modulation specifically in the post-prandial state.
Programme
Travel Awards - Institute Community Support
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
382932
Name
Boyer Marjorie
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
ICRH - International Symposium on Atherosclerosis (ISA) Travel Awards
Projecttitle
Associations between plasma PCSK9 levels and postprandial lipemia markers in abdominally obese men with dyslipidemia undergoing lifestyle modification therapy
Programtype2
Undefined
Orgnameinp2
Université Laval
Cihramount2
$1,000
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Ics Travel Awards
Abstract
High LDL cholesterol levels is an important cardiovascular disease (CVD) risk factor. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been identified as a crucial LDL cholesterol level regulator. However, mechanisms regulating PCSK9 remain unclear specifically after meals in the post-prandial state. Lifestyle modification programs are the cornerstone of CVD management. We have measured PCSK9 levels, during a high fat meal and every 2h for 8h, in men with abdominal obesity and dyslipidemia before and after a 1-year lifestyle modification program. PCSK9 levels decreased during a high fat meal before and after the lifestyle intervention. After the 1 year lifestyle intervention PCSK9 levels were reduced at each time point of the high fat meal. The positive impact of a healthy lifestyle on CVD risk could be through PCSK9 modulation specifically in the post-prandial state.
Competitiondate
201802
Approvedterm2
1 yr 0 mth
Pinamesdelim
Boyer, Marjorie
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Circ &Respiratory Hlth~ $1,000~ $0~
