Grant: Discovery Grants Program - Individual
York University
$42,400.00
Molecular architecture in gene expression and virus-host interactions
EF 2015-16
Résumé
The aim of my research is to understand how proteins assemble into an architecture that is well suited to a specific function. The atomic level of detail required to visualize differences in protein assemblies is achieved by using techniques such as NMR spectroscopy and X-ray crystallography that are available locally to my laboratory. The three aims in my proposal cover three general areas of cell signaling. The first aim examines how a pair of Sox9 proteins working together is capable of activating a different developmental program in a cell than one Sox9 protein working alone. The second aim examines the nature of the interactions between a bacterial transcription factor and its promoters that drive antibiotic resistance. The third aim examines how a bacterial genetic program is altered during viral infection by a protein called ea8.5. The basic research described in this proposal will be used to understand the new aspects of cell signaling and help design selective therapies against disease.
Programme
Discovery Grants Program - Individual
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
238934-2011
Name nom
Donaldson, Logan
Department département
Biology
Organization id
38
Institution établissement
York University
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2015
Competition year année de concours
2011
Award amount
42400
Program id
RGPIN
Program name en
Discovery Grants Program - Individual
Program name fr
Programme de subventions à la découverte - individuelles
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
1501
Committee name en
Genes, Cells and Molecules
Committee name fr
Gènes, cellules et molécules
Area of application code
1101
Area of application group en
Health, education and social services
Area of application group fr
Santé publique, éducation et services sociaux
Area of application en
Human health (including medically-related psychological research)
Area of application fr
Santé publique (y compris recherche psychologique liée à la médecine)
Research subject code
5403
Research subject group en
Biochemistry
Research subject group fr
Biochimie
Research subject en
Proteins and peptides, amino acids
Research subject fr
Protéines et peptides, acides aminés
Partie
5
Nb partie
5
Application title
Molecular architecture in gene expression and virus-host interactions
Keyword
NSERC
Application summary
The aim of my research is to understand how proteins assemble into an architecture that is well suited to a specific function. The atomic level of detail required to visualize differences in protein assemblies is achieved by using techniques such as NMR spectroscopy and X-ray crystallography that are available locally to my laboratory. The three aims in my proposal cover three general areas of cell signaling. The first aim examines how a pair of Sox9 proteins working together is capable of activating a different developmental program in a cell than one Sox9 protein working alone. The second aim examines the nature of the interactions between a bacterial transcription factor and its promoters that drive antibiotic resistance. The third aim examines how a bacterial genetic program is altered during viral infection by a protein called ea8.5. The basic research described in this proposal will be used to understand the new aspects of cell signaling and help design selective therapies against disease.
