Grant: Project Grant

Staphylococcus aureus is a pathogenic bacterium causing a wide range of hospital- and community-acquired infections. As such, this organism remains a major health burden. An early and critical step in the establishment of infection is the attachment of the bacterium to the surface of our skin and to the skin-like linings (mucosae) within our bodies. This research proposal is positioned to gain insight into the mechanisms used by S. aureus to enable these processes. Previously, we deciphered the network of genes important for adhesion. Building upon this milestone, here we focus on the mechanisms contributing to the surface presentation and stability of the surface appendages used by S. aureus to adhere to the body. This information will be used to inform a concurrent study where we are taking aim at adhesion with small molecule inhibitors. Such molecules could represent a novel class of therapeutics to prevent and control S. aureus infections. The development of alternatives, or complementary therapeutics to enhance antibiotic action, could reduce the severity of the antibiotic resistance crisis.