Grant: Operating Grant
University of British Columbia
$805,404.00
Synaptic and Nonsynaptic modulation of neuronal excitability
EF 2010-11
Résumé
The research proposed in this grant will investigate novel types of interactions between neurons that are important for generating the aura of migraines, in causing the neuronal swelling underlying cytotoxic brain edema and in allowing the immune cells of the brain, called microglia, to sense when intense activation and damage occurs in nearby neurons. Each of these pathways involves a new form of transmitter release and reveals the potential cytotoxic impact of ionic disruptions in nerve cells.
Programme
Operating Grant
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
225633
Name
MacVicar Brian A
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Synaptic and Nonsynaptic modulation of neuronal excitability
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$805,404
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Atp Release; Brain Slice; Calcium Channels; Dendrite; Imaging Intracellular Sodium; Intracellular Choride; Microglia; Neuronal Edema; Two Photon Laser Scanning Microscope
Abstract
The research proposed in this grant will investigate novel types of interactions between neurons that are important for generating the aura of migraines, in causing the neuronal swelling underlying cytotoxic brain edema and in allowing the immune cells of the brain, called microglia, to sense when intense activation and damage occurs in nearby neurons. Each of these pathways involves a new form of transmitter release and reveals the potential cytotoxic impact of ionic disruptions in nerve cells.
Competitiondate
201103
Approvedterm2
5 yrs 0 mth
Pinamesdelim
MacVicar, Brian A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $805,404~ $0~
