Grant: Emerging Team Grant: HIV/AIDS Vaccine Discovery & Social Research
University of Toronto
$1,250,000.00
CIHR Team in HIV Vaccine Design Based on Novel Strategies to Induce Protective Mucosal Cellular and Humoral Immunity
EF 2009-10
Résumé
This project involves basic science HIV vaccine research. We propose to develop and test two vaccine candidates. Both vaccine projects will involve molecular biological techniques to construct the vaccines and test them for expression. The first project involves the construction of a Cytomegalovirus-based vaccine vector expressing green fluorescent protein and SIV gene inserts. The second project involves the development of a complex DNA vaccine based on a fusion protein of two trimerized proteins: one of gp140 and the other of a TNF superfamily molecule. Other innate immune molecules will also be tested for potential incorporation into the model. Small animal models and in vivo methods will be used to examine immunogenicity. Further testing involving immunological methods as well as molecular and retrovirology will be done in rabbits and nonhuman primates.
Programme
Emerging Team Grant: HIV/AIDS Vaccine Discovery & Social Research
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
204885
Name
Macdonald Kelly S
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Emerging Team Grant : HIV/AIDS Vaccine Discovery and Social Research
Projecttitle
CIHR Team in HIV Vaccine Design Based on Novel Strategies to Induce Protective Mucosal Cellular and Humoral Immunity
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$1,250,000
Cihrequipment2
$0
Programname2
Emerging Team Grant: HIV/AIDS Vaccine Discovery & Social Research
Keyworddelim
Cytomegalovirus; Hiv Vaccine; Immunoregulation; Innate Immunity; Neutralizing Antibody
Abstract
This project involves basic science HIV vaccine research. We propose to develop and test two vaccine candidates. Both vaccine projects will involve molecular biological techniques to construct the vaccines and test them for expression. The first project involves the construction of a Cytomegalovirus-based vaccine vector expressing green fluorescent protein and SIV gene inserts. The second project involves the development of a complex DNA vaccine based on a fusion protein of two trimerized proteins: one of gp140 and the other of a TNF superfamily molecule. Other innate immune molecules will also be tested for potential incorporation into the model. Small animal models and in vivo methods will be used to examine immunogenicity. Further testing involving immunological methods as well as molecular and retrovirology will be done in rabbits and nonhuman primates.
Competitiondate
201003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Macdonald, Kelly S
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,250,000~ $0~
