Grant: Project Grant
University of British Columbia
$918,000.00
In Vivo Modeling of EBV's role in the development of Multiple Sclerosis
EF 2019-20
Résumé
As EBV does not infect mice, we employ a two-fold approach to experimentally address this complex mechanism. We previously chose to study the EBV murine homolog, gammaherpesvirus 68 (¿-HV68), in mouse models of EAE. In this proposal, we take the second approach by modeling mice for susceptibility to EBV infection with human immune systems to directly experimentally test this mechanism. In this manner, the goal of this project is to decipher the molecular and cellular changes that occur during latent EBV infection that increase the susceptibility and progression of MS, specifically herein, to examine the influence the target of latent infection, B cells.
Programme
Project Grant
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
409259
Name
Horwitz Marc S
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
In Vivo Modeling of EBV's role in the development of Multiple Sclerosis
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$918,000
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Eae; Epstein-Barr Virus; Human Immunology; Interferon; Memory B Cells; Multiple Sclerosis
Abstract
As EBV does not infect mice, we employ a two-fold approach to experimentally address this complex mechanism. We previously chose to study the EBV murine homolog, gammaherpesvirus 68 (¿-HV68), in mouse models of EAE. In this proposal, we take the second approach by modeling mice for susceptibility to EBV infection with human immune systems to directly experimentally test this mechanism. In this manner, the goal of this project is to decipher the molecular and cellular changes that occur during latent EBV infection that increase the susceptibility and progression of MS, specifically herein, to examine the influence the target of latent infection, B cells.
Competitiondate
201909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Horwitz, Marc S
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $918,000~ $0~
