Grant: Operating Grant

It is well established that obesity is a major risk factor for diabetes. However, the precise mechanisms responsible for regulating changes in insulin sensitivity and energy metabolism remain to be fully determined. This project will focus on the role played by a substance (adiponectin) which is released from fat cells. Upon release, adiponectin can travel in the bloodstream to have effects in peripheral metabolic tissues such as skeletal muscle and liver. Interestingly, the amount of adiponectin circulating in the blood decreases in obese and diabetic individuals. We intend to determine how too little adiponectin alters insulin sensitivity and energy metabolism. Understanding this may facilitate development of new treatments to reduce morbidity and mortality in individuals with obesity and diabetes.