Grant: Operating Grant: TRANSCAN-3
University of British Columbia
$448,770.00
Unveiling the Epigenetic Landscape and Therapeutic Implications of Epigenetic Modifiers in Human T-cell Leukemia Initiation and Progression
EF 2023-24
Résumé
T-cell acute lymphoblastic leukemia, or "T-ALL", is a type of blood cancer that often relapses, often due to changes in a patient's DNA that makes it more difficult to target genes that moderate cancer development and progression. We aim to learn more about how T-ALL cancer grows by understanding more about the cell's environment and its effects on genes and their role in cancer therapy resistance and relapse. We will use a novel mode that turns off/on related genes and then evaluate the effect cancer growth and survival.
Programme
Operating Grant: TRANSCAN-3
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
498158
Name
Weng Andrew P
Region
British Columbia
Country
Canada
Orgtype
Research Institution; Institution Paid
Partnername
German Federal Ministry of Research, Technology and Space (Berlin); National Research Fund (Luxembourg); Ministero della Salute (Italy)
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Special Cases
Projecttitle
Unveiling the Epigenetic Landscape and Therapeutic Implications of Epigenetic Modifiers in Human T-cell Leukemia Initiation and Progression
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$448,770
Cihrequipment2
$0
Programname2
Operating Grant: TRANSCAN-3
Keyworddelim
Carcinogenesis; Crispr-Cas Systems; Epigenomics; Guide; Leukemia; Rna; Single-Cell Gene Expression Analysis; T-Cell
Abstract
T-cell acute lymphoblastic leukemia, or "T-ALL", is a type of blood cancer that often relapses, often due to changes in a patient's DNA that makes it more difficult to target genes that moderate cancer development and progression. We aim to learn more about how T-ALL cancer grows by understanding more about the cell's environment and its effects on genes and their role in cancer therapy resistance and relapse. We will use a novel mode that turns off/on related genes and then evaluate the effect cancer growth and survival.
Competitiondate
202312
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Weng, Andrew P
Approvedterm
3 ans 0 mois
Cihrcontribution2
ICR~ $448,770~ $0~
