Grant: Emerging Team Grant: From Genes to Proteins, Cells, Tissues and Patients - LOI

Our ambitious and innovative proposal on vitamin B12 aims to enhance translation of gene and protein research to medicine. It will generate new knowlege about inherited diseases involving this important vitamin and apply insights to common problems involving patients and populations. More specific objectives include studies on how gene products interact using a variety of technologies derived from microbiology and protein science. We will exploit mouse models to study birth defects and the effect of treating mothers during pregnancy on preventing developmental abnormalities. Using small molecule screeing, we aim to identify compounds that can bind proteins of choice, enabling exploration of specific metabolic pathways and targeted therapeutic approaches.