Grant: Project Grant
University of Toronto
$807,075.00
The role of reticulon homology domain (RHD) protein and related family members in the sarco(endo)plasmic formation and regulation in the cardiac myocyte
EF 2023-24
Résumé
There is a specialized region of the cardiac cell, called the endo(sarco)plasmic reticulum. We have been studying this organelle for over 20 years and are interested in how it is formed, how it regulates the cardiac cell beating, and what happens when it does not function correctly. Here we will focus on some of the core proteins we believe are essential for the formation and maintenance of this highly specialized region of the cell. In fact, mutations of these proteins that are expressed in other cells have been shown to cause numerous genetic disease including in neurons and skeletal muscle, highlighting that these proteins are essential for normal functioning in highly differentiated cells.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
488705
Name
Gramolini Anthony O
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cardiovascular System - B: Heart and Circulation
Projecttitle
The role of reticulon homology domain (RHD) protein and related family members in the sarco(endo)plasmic formation and regulation in the cardiac myocyte
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$807,075
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cardiomyocyte; Endoplasmic Reticulum; Myopathy; Organellar Development
Abstract
There is a specialized region of the cardiac cell, called the endo(sarco)plasmic reticulum. We have been studying this organelle for over 20 years and are interested in how it is formed, how it regulates the cardiac cell beating, and what happens when it does not function correctly. Here we will focus on some of the core proteins we believe are essential for the formation and maintenance of this highly specialized region of the cell. In fact, mutations of these proteins that are expressed in other cells have been shown to cause numerous genetic disease including in neurons and skeletal muscle, highlighting that these proteins are essential for normal functioning in highly differentiated cells.
Competitiondate
202309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Gramolini, Anthony O
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $807,075~ $0~
