Grant: Summer Program in Aging

This research focuses on understanding why cognitive decline, or worsening memory and thinking problems, occur faster in older breast cancer survivors who have undergone chemotherapy. While chemotherapy has significantly improved survival rates, it may contribute to health changes that affect cognitive function. Many survivors experience declines in lifestyle habits like physical activity levels, nutrition, stress management, and sleep, alongside changes in blood health markers like cholesterol and blood sugar levels. These changes may lead to blood vessel damage (e.g. structural or functional) over time, increasing the risk of both brain and heart health issues. The causes of accelerated cognitive decline in survivors remain unclear due to the complexity of contributing factors. This research will examine how lifestyle habits, blood health markers, and blood vessel health affect cognitive function in breast cancer survivors aged 60-85 who previously completed chemotherapy. By assessing areas of cognitive function like memory, language, and attention, and analyzing blood vessel health, we aim to identify which risk factors may speed up or slow down cognitive decline. Understanding these associations will allow us to develop more tailored, supportive care plans and enhance quality of life and independence for older adults. This research addresses health complexities in aging, promoting wellness, and reducing health inequities through research focused on older adults, particularly older women who face unique health risks. Findings from this research may help to inform post-chemotherapy treatment guidelines to prevent cognitive impairment and better address the specific needs of this historically underrepresented group in research. Moreover, this research may guide future interventions aiming to improve personal health, support population health initiatives, and provide insights for the healthcare system about caring for older breast cancer survivors.