Grant: Training Grant

Understanding protein folding and protein interactions is one of the central concerns in biology. While the structure of the protein native state is dictated by the amino acid sequence of the protein, the mechanisms of spontaneous and chaperone-assisted folding remain elusive. Furthermore, the mechanisms by which protein aggregation causes neurotoxicity is also poorly understood. Building on our previous six years of funding, the CIHR Training Program in "Protein Folding and Interaction Dynamics: Principles and Diseases" will facilitate research into these fundamental questions by providing an excellent training environment and by encouraging the use of multidisciplinary and transdisciplinary approaches. Our program brings together scientists from various disciplines to encourage cross-disciplinary research encompassing computational, in vitro, in vivo, and disease-related aspects of protein folding.