Grant: Travel Awards - Institute Community Support
Direct Payment
$940.00
Myeloid derived suppressor cells down-regulate airway allergic inflammation and remodeling
EF 2011-12
Résumé
Asthma, affecting approximately 10% of the population, is a chronic inflammatory disease of the airways, often leading to irreversible loss of lung function. Asthma is caused by the expansion of subsets of T cells-Th2 and Th17 cells; while Treg cells, reduced in asthma, are able to inhibit allergic responses. Myeloid derived suppressor cells (MDSCs) are a newly discovered population of cells which have a remarkable ability to suppress T cell responses and to induce the expansion of Treg cells. Due to these abilities, MDSCs may ameliorate asthma where T cells are dysfunctional.
In this abstract, our results showed that injection of in vitro-generated MDSCs ameliorated allergic airway inflammation, which indicated that it might be useful for the treatment of asthma.
Programme
Travel Awards - Institute Community Support
Bénéficiaire
Emplacement
Manitoba, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
252638
Name
Guan Qingdong
Region
Manitoba
Country
Canada
Orgtype
Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Institute of Circulatory and Respiratory Health
Projecttitle
Myeloid derived suppressor cells down-regulate airway allergic inflammation and remodeling
Programtype2
Undefined
Orgnameinp2
Direct Payment
Cihramount2
$940
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Asthma; Myeloid Derived Suppressor Cells
Abstract
Asthma, affecting approximately 10% of the population, is a chronic inflammatory disease of the airways, often leading to irreversible loss of lung function. Asthma is caused by the expansion of subsets of T cells-Th2 and Th17 cells; while Treg cells, reduced in asthma, are able to inhibit allergic responses. Myeloid derived suppressor cells (MDSCs) are a newly discovered population of cells which have a remarkable ability to suppress T cell responses and to induce the expansion of Treg cells. Due to these abilities, MDSCs may ameliorate asthma where T cells are dysfunctional.
In this abstract, our results showed that injection of in vitro-generated MDSCs ameliorated allergic airway inflammation, which indicated that it might be useful for the treatment of asthma.
Competitiondate
201201
Approvedterm2
0 yr 1 mth
Pinamesdelim
Guan, Qingdong
Approvedterm
0 an 1 mois
Cihrcontribution2
Inst of Circ &Respiratory Hlth~ $940~ $0~
