Grant: Operating Grant

Paget's disease of bone (PDB) is a chronic disorder that can result in enlarged and misshapen bones. The excessive breakdown and formation of bone tissue causes affected bone to weaken - resulting in bone pain, misshapen bones, or fractures. Bone abnormalities are due to an over-activity of the cells that normally keep bones strong and healthy. A genetic mutation identified in many patients with PDB may be the key to discovering what is causing their bones to weaken. We are investigating the effects of this mutation on bone cells. We will study bone cells from precursors present in umbilical cord blood, as well as from blood of patients presenting with Paget's disease of bone. Our studies may then provide a better understanding of bone abnormalities and help in the identification of new therapeutic targets for PDB.