Grant: Project Grant

Adult stem and progenitor cells play fundamental roles in tissue homeostasis, renewal and regeneration, and when these cells become dysfunctional, they likely increase the pace of aging. My laboratory is particularly focused on one type of adult stem/progenitor cell termed a mesenchymal progenitor (MP) and their role in tissue renewal, regeneration, and aging. In accelerated aging conditions such as Hutchinson Gilford progeria syndrome (HGPS) it has been suggested that aberrant MPs make a substantial contribution to this disorder. HGPS is associated with a single base mutation in the Lamin A gene, and mice harboring this mutation also exhibit signs of accelerated aging. Numerous research groups have also shown that progerin accumulates in our cells during the course of normal aging. Using recently created novel mouse lines we will directly test the hypothesis that progerin expression in MPs contributes to aging. If this can be demonstrated, these studies will provide critical experimental evidence supporting a prominent role for MPs in aging. This information will lead to a better understanding of the aging process, while also providing a foundation to support therapeutic strategies aimed at enhancing healthy aging.