Grant: CIHR New Investigator
Centre hospitalier de l'Université de Montréal (CHUM)
$300,000.00
Impact of TDP-43 in stress granule signaling in ALS
EF 2011-12
Résumé
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by the selective loss of specialized neurons that control voluntary movement. The mechanism and the biological basis of specificity of how these specialized neurons, known as motor neurons, are lost in ALS remains unknown. Environmental and genetics components both play a role in disease etiology. Motor neurons are inherently more susceptible to exposure to stress stimuli. Mammalian cells possess a variety of mechanisms to mediate a cell's recovery from physiological and environmental stresses. I have recently identified TAR DNA binding protein (TDP-43) as a regulator of one cellular stress response: the formation of stress granules. I propose to examine the role of wild type and mutated TDP-43 (a known ALS causing gene) in stress granule signalling and ALS pathogenesis.
Programme
CIHR New Investigator
Emplacement
Quebec, Canada
Type de bénéficiaire
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
241273
Name
Vande Velde Christine Diane C
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
New Investigators C
Projecttitle
Impact of TDP-43 in stress granule signaling in ALS
Programtype2
Salary Programs
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$300,000
Cihrequipment2
$0
Programname2
CIHR New Investigator
Keyworddelim
Amyotrophic Lateral Sclerosis; Biochemistry; Oxidative Stress; Rna-Binding Protein; Spinal Cord; Stress Granules; Tdp-43
Abstract
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by the selective loss of specialized neurons that control voluntary movement. The mechanism and the biological basis of specificity of how these specialized neurons, known as motor neurons, are lost in ALS remains unknown. Environmental and genetics components both play a role in disease etiology. Motor neurons are inherently more susceptible to exposure to stress stimuli. Mammalian cells possess a variety of mechanisms to mediate a cell's recovery from physiological and environmental stresses. I have recently identified TAR DNA binding protein (TDP-43) as a regulator of one cellular stress response: the formation of stress granules. I propose to examine the role of wild type and mutated TDP-43 (a known ALS causing gene) in stress granule signalling and ALS pathogenesis.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Vande Velde, Christine Diane C
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $300,000~ $0~
