Grant: Canada Research Chairs
University of Manitoba
$200,000.00
Canada Research Chair in Structural Biology
EF 2023-24
Résumé
A molecular understanding of the structure-property relationships of extracellular proteins involved in (i) the formation of dynamic high-order signaling complexes related to human disease and (ii) the establishment of unique S-layer assemblies from extremophilic archea is essential for the development of structure-based applications in the fields of biomedicine and biotechnology. The exploration of structural dynamics of proteins in cellular communication and cell-matrix signaling are of great biomedical importance. In a second avenue of research, we are exploiting S-layer coiled coils to design industry applicable monitoring and remediation tools. The development of structure-guided applications based on the unique features of coiled-coil nanotubes is a new approach in application-driven research. We will continue to apply and develop further an integrated research program combining high-resolution structural biology techniques, with various biophysical and functional approaches.
Programme
Canada Research Chairs
Bénéficiaire
Emplacement
Manitoba, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
CRC-2016-00259
Name nom
Stetefeld, Jörg
Department département
Chemistry and Microbiology - University of Manitoba
Organization id
19
Institution établissement
University of Manitoba
Province en
Manitoba
Province fr
Manitoba
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2023
Competition year année de concours
2016
Award amount
200000
Program id
CRC
Program name en
Canada Research Chairs
Program name fr
Chaires de recherche du Canada
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
9998
Committee name en
Canada Research Chair Selection Committee
Committee name fr
Comité de sélection des Chaires de recherche du Canada
Area of application code
9999
Area of application group en
Not available
Area of application group fr
Non disponible
Area of application en
Not available
Area of application fr
Non disponible
Research subject code
10000
Research subject group en
The field of research available
Research subject group fr
The field of research available
Research subject en
Le domaine de recherche disponible
Research subject fr
Le domaine de recherche disponible
Field of research list codes
RDF10601;RDF20501
Field of research list names en
Biochemistry;Chemical engineering
Field of research list names fr
Biochimie;Génie chimique
Application title
Canada Research Chair in Structural Biology
Keyword
Higher-order signaling complexes
Protein-Protein networks
Netrin
Dependence receptor complexes
Right-handed coiled coils
S-layer assembly
Monitoring and Remediation
Structural Biophysics
Biochemistry
X-ray crystallography
SAXS
Integrated Approach
Hydrodynamic properties
Application summary
A molecular understanding of the structure-property relationships of extracellular proteins involved in (i) the formation of dynamic high-order signaling complexes related to human disease and (ii) the establishment of unique S-layer assemblies from extremophilic archea is essential for the development of structure-based applications in the fields of biomedicine and biotechnology. The exploration of structural dynamics of proteins in cellular communication and cell-matrix signaling are of great biomedical importance. In a second avenue of research, we are exploiting S-layer coiled coils to design industry applicable monitoring and remediation tools. The development of structure-guided applications based on the unique features of coiled-coil nanotubes is a new approach in application-driven research. We will continue to apply and develop further an integrated research program combining high-resolution structural biology techniques, with various biophysical and functional approaches.
