Grant: Research Tools and Instruments - Category 1 (<$150,000)
University of Alberta
$146,651.00
Triple Quadrupole Gas Chromatography - Tandem Mass Spectrometry (GCMS/MS) Instrument with Electron Ionization and Chemical Ionization
EF 2011-12
Résumé
We are applying for funding to purchase an instrument that is capable of both qualitative and quantitative analysis of compounds. The instrument is a gas chromatograph coupled to a triple quadrupole mass spectrometer (MS). The mass spectrometer has two ionization sources, i) a standard electron ionization source used to both identify unknown compounds through mass spectral fingerprinting and to determine how much material is present and ii) a softer chemical ionization source used to determine molecular mass and also used in the determination of how much material is present. The triple quadrupole mass spectrometer has the capability to operate in MS/MS mode which provides greatly improved signal-to-noise and specificity allowing one to determine ""how much"" of a given material is present even in very complex mixtures. This instrument will be used to support medicinal chemistry synthesis including probes for cancer detection, the characterization of anti-bacterial peptides, the determination of biomarkers of diseases such as breast and lung cancers, and the analysis of other very complex mixtures.
Programme
Research Tools and Instruments - Category 1 (<$150,000)
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
422404-2012
Name nom
Hall, Dennis
Department département
Chemistry
Organization id
9
Institution établissement
University of Alberta
Province en
Alberta
Province fr
Alberta
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2011
Competition year année de concours
2012
Award amount
146651
Program id
EQPEQ
Program nane en
Research Tools and Instruments - Category 1 (<$150,000)
Program name fr
Outils et instruments de recherche - catégorie 1 (<150 000$)
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
1504
Committee name en
Chemistry
Committee name fr
Chimie
Area of application code
1200
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Advancement of knowledge
Area of application fr
Avancement des connaissances
Research subject code
3700
Research subject group en
Organic chemistry
Research subject group fr
Chimie organique
Research subject en
Organic chemistry
Research subject fr
Chimie organique
Partie
1
Nb partie
1
Application title
Triple Quadrupole Gas Chromatography - Tandem Mass Spectrometry (GCMS/MS) Instrument with Electron Ionization and Chemical Ionization
Keyword
NSERC
Application summary
We are applying for funding to purchase an instrument that is capable of both qualitative and quantitative analysis of compounds. The instrument is a gas chromatograph coupled to a triple quadrupole mass spectrometer (MS). The mass spectrometer has two ionization sources, i) a standard electron ionization source used to both identify unknown compounds through mass spectral fingerprinting and to determine how much material is present and ii) a softer chemical ionization source used to determine molecular mass and also used in the determination of how much material is present. The triple quadrupole mass spectrometer has the capability to operate in MS/MS mode which provides greatly improved signal-to-noise and specificity allowing one to determine ""how much"" of a given material is present even in very complex mixtures. This instrument will be used to support medicinal chemistry synthesis including probes for cancer detection, the characterization of anti-bacterial peptides, the determination of biomarkers of diseases such as breast and lung cancers, and the analysis of other very complex mixtures.
