Grant: Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Sunnybrook Research Institute (Toronto, Ontario)
$105,000.00
Increasing cognitive performance, neuronal plasticity and survival using non-invasive delivery of neurotrophic genes
EF 2015-16
Résumé
This experiment will investigate the therapeutic potential of non-invasive gene delivery for the treatment of Alzheimer's disease (AD). We propose delivering brain derived neurotrophic factor (BDNF) or a BDNF receptor-specific agonist to the brain using MRI-guided focused ultrasound. The results of these experiments could demonstrate a novel AD treatment strategy using targeted gene delivery to restore memory.
Programme
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Bénéficiaire
Emplacement
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
348000
Name
Weber-Adrian Danielle
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Doctoral Research Awards - A
Projecttitle
Increasing cognitive performance, neuronal plasticity and survival using non-invasive delivery of neurotrophic genes
Programtype2
Studentship Programs
Orgnameinp2
Sunnybrook Research Institute (Toronto, Ontario)
Cihramount2
$105,000
Cihrequipment2
$0
Programname2
Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships
Keyworddelim
Adeno-Associated Virus; Alzheimer'S Disease; Brain-Derived Neurotrophic Factor (Bdnf); Gene Therapy; Mri-Guided Focused Ultrasound
Abstract
This experiment will investigate the therapeutic potential of non-invasive gene delivery for the treatment of Alzheimer's disease (AD). We propose delivering brain derived neurotrophic factor (BDNF) or a BDNF receptor-specific agonist to the brain using MRI-guided focused ultrasound. The results of these experiments could demonstrate a novel AD treatment strategy using targeted gene delivery to restore memory.
Competitiondate
201510
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Weber-Adrian, Danielle
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $105,000~ $0~
