Contribution: Industrial Research Assistance Program

Kapoose Creek Bio will adapt our existing AI-enabled phenotypic profiling platform for chemical threat assessment. Unlike chemistry-first detection that requires knowing what to look for, our activity-based approach identifies biological mechanism of action regardless of chemical novelty detecting even never-before-seen agents, such as novel derivatives that would evade traditional methods. The platform uses high-content cell imaging combined with Random Forest machine learning, leveraging a training set of 13,000+ bioactive compounds with known activity and mechanism. We will build a reference atlas of ~100 threat-relevant agents to further train mechanism classification. This capability will provide actionable intelligence within 48h.