Program directory · National Research Council Canada
Human Health Therapeutics
- Department
- National Research Council Canada
- Program code
- BNQ07 (NRC)
- Core responsibility
- Science and Innovation
- In Departmental Plans
- 2018-19 – 2026-27 · New since an earlier plan
What it does
Through research and development of biotherapeutics, vaccines and technology platforms, the Human Health Therapeutic (HHT) program aims to transform human health outcomes for the benefit of society. HHT primarily serves the needs of small and medium enterprises (SMEs) from the Canadian biopharmaceutical industry, although it is also involved in federal government collaborative research aimed at creating solutions for public health issues affecting the lives of Canadians. HHT serves its clients and collaborators through three main mechanisms: it enters collaborative research agreements to co-develop products and technologies, it provides testing or advisory services that result in different types of information being delivered to the client, and it licenses out off-the-shelf products and technology platforms developed and owned by the program. The program directly improves the R&D and innovation capabilities of SME clients through knowledge and technology transfer while also allowing these companies to advance their biologics and vaccine pipelines by de-risking product development and manufacturing activities. HHT will soon enable the production of clinical trial material for its clients through a state of the art GMP compliant Clinical Trial Manufacturing Facility. All of this is expected to lead clients to submit for regulatory approvals, launch clinical trials and eventually commercialize novel products. HHT is ultimately expected to help Canadian biopharmaceutical companies become more competitive on the national and global stages, attract new funding and grow to scale in Canada. HHT also has a role to play in coordinating public health research efforts within the federal government so that public good solutions, such as vaccines to combat infectious diseases or therapeutics to treat rare disorders, can be developed and deployed and so that Canada is in a better position to respond to future public health crises.
Source: the department's Program Inventory, via GC InfoBase.
History and lineage
First appears in GC InfoBase's actual spending by program in 2018-19. The data does not record when a program was created; it may be older than its first appearance here, which is limited by the sources (program spending starts in 2010-11, Departmental Plans in 2018-19).
| Program | Relation | Years with data | Actual spending over those years |
|---|---|---|---|
| Human Health Therapeutics | This program | 2018-19 – 2028-29 | $576M |
No earlier or later program in the same department has a similar name.
Significant changes in scope and budget
Detected from the data: renames between plans, programs it appears to replace, merge with or split into (matched by name), year-over-year changes in spending of at least 25% and $5M, or in employees of at least 20% and 25 FTEs, linked budget measures, and results indicators added or dropped.
| Year | What changed | Source |
|---|---|---|
| 2020-21 | Spending $96.2M, against $50.8M in 2019-20 (+89%). | Actual spending (GC InfoBase) |
| 2021-22 | Employees (FTEs) 398, against 331 in 2020-21 (+20%). | FTEs (GC InfoBase) |
| 2021-22 | Indicators added: Citation score of Human Health Therapeutics generated publications relative to world average; Number of contractual agreements with other government departments; Number of patent applications filed; Revenue earned from all external research clients | Departmental Results Framework (GC InfoBase) |
| 2021-22 | Indicators dropped: Number of clients and collaborators working with the Research Centre annually; Number of unique intellectual assets generated by Research Centre employees; Value of external contributions to Research Centre research and development services and scientific and technological infrastructure | Departmental Results Framework (GC InfoBase) |
| 2021-22 | Spending $131M, against $96.2M in 2020-21 (+36%). | Actual spending (GC InfoBase) |
| 2023-24 | Employees (FTEs) 327, against 420 in 2022-23 (−22%). | FTEs (GC InfoBase) |
| 2023-24 | Spending $58.7M, against $125M in 2022-23 (−53%). | Actual spending (GC InfoBase) |
Success criteria
The program's indicators from its department's Departmental Results Framework: the target set in each year's plan, and the result reported the following year. Source: GC InfoBase.
Historical: targets against results
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2021-22 | ≥ 1.05 | 2022 | 1.22 | Met |
| 2022-23 | ≥ 1.05 | 2023 | 1.44 | Met |
| 2023-24 | ≥ 1.05 | 2024 | 1.25 | Met |
| 2024-25 | ≥ 1.2 | 2025 | 1.19 Not required (essentially met). | Not met |
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2021-22 | ≥ 3 | 2022 | 11 | Met |
| 2022-23 | ≥ 3 | 2023 | 8 | Met |
| 2023-24 | ≥ 6 | 2024 | 5 Agreements with OGDs do fluctuate from year to year and +1 or -1 is not unusual. Another agreement in development is pending. | Not met |
| 2024-25 | ≥ 3 | 2025 | 11 | Met |
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2021-22 | ≥ 100 | 2022 | 86 HHT’s overall number of patent applications were within the expected range. First filing patent applications in any jurisdiction were up 200% in 2021-22 compared to the previous year, indicating that the results do not reflect a shortage of new inventions with commercial potential. Additionally, jurisdictions were targeted more selectively to manage escalating patent costs and some filings were d… | Not met |
| 2022-23 | ≥ 50 | 2023 | 58 | Met |
| 2023-24 | ≥ 50 | 2024 | 89 | Met |
| 2024-25 | ≥ 60 | 2025 | 74 | Met |
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2021-22 | ≥ $10M | 2022 | $13M | Met |
| 2022-23 | ≥ $12M | 2023 | $16.8M | Met |
| 2023-24 | ≥ $12M | 2024 | $7.2M There is a fundamental shift in the business environment for many of HHT's traditional clients and partners who are struggling to find financing. HHT's outreach approach is now pivoting toward the new market directions, such as biomanufacturing and Cell and Gene Therapy (CGT), which are well-aligned with HHT's 2024-2029 Strategic Plan and expected to augment client interactions. | Not met |
| 2024-25 | ≥ $12M | 2025 | $12.1M | Met |
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2018-19 | ≥ 112 | 2019 | 103 The number of agreements for the 2018-19 fiscal year was slightly lower than planned. In 2018-19, the Human Health and Therapeutics (HHT) program was engaged in the design and launch of the challenge program in Disruptive Technology Solutions for Cell and Gene therapy, which involved broad outreach to academic communities. It is anticipated that the resulting collaborations will be formalized in… | Not met |
| 2019-20 | ≥ 100 | 2020 | 118 | Met |
| 2020-21 | ≥ 95 | 2021 | 72 In order to comply with public health measures associated with the COVID-19 pandemic, Human Health Therapeutics had to restrict on-site activities to focus on pandemic response priority projects, thus cancelling or postponing many projects with clients and collaborators. | Not met |
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2018-19 | ≥ 118 | 2019 | 98 Peer reviewed publications were under the projected 8% growth as a result of the shift in research priorities which take more time than anticipated to generate publications. The change in our innovation strategy to focusing on larger technology bundles led to fewer disclosures. However, prior and current disclosures led to more patent filings. | Not met |
| 2019-20 | ≥ 108 | 2020 | 126 | Met |
| 2020-21 | ≥ 116 | 2021 | 111 Target was essentially met. | Not met |
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2018-19 | ≥ $13M | 2019 | $12.2M The new strategy for the Human Health and Therapeutics (HHT) program is to focus on value-added co-development with partner institutions, to build a pipeline of new Canadian therapies. As a result, in 2018-19, HHT was more selective in pursuing revenue-generating activities, resulting in less revenue generated than was originally anticipated. | Not met |
| 2019-20 | ≥ $12.9M | 2020 | $11.7M In 2019-20, Human Health Therapeutics continued its shift toward public good-driven initiatives, in collaboration with other government departments and academia namely, with the Cell and Gene Therapy Challenge Program. Similarly, on the business side, the focus was more on co-development with small and medium-sized entreprises and less on service agreements. These provide more limited revenue inp… | Not met |
| 2020-21 | ≥ $12M | 2021 | $8.9M In order to comply with public health measures associated with the COVID-19 pandemic, Human Health Therapeutics had to restrict on-site activities to focus on pandemic response priority projects, thus cancelling or postponing many revenue generating services normally provided. | Not met |
Current: the 2026-27 plan's targets
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2026-27 | ≥ 1.2 | 2027 | — | Planned |
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2026-27 | ≥ 3 | 2027 | — | Planned |
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2026-27 | ≥ 60 | 2027 | — | Planned |
Bars: result reported. Dashed line: target.
| Report year | Target | Due | Result | Status |
|---|---|---|---|---|
| 2026-27 | ≥ $12.4M | 2027 | — | Planned |
Future goals: targets due after 2026-27
No targets with a later due date.
Spending and employees: planned against actual
Spending
Show the numbers
| Fiscal year | Planned | Actual |
|---|---|---|
| 2018-19 | $39.7M | $47.8M |
| 2019-20 | $44.4M | $50.8M |
| 2020-21 | $46.4M | $96.2M |
| 2021-22 | $92.2M | $131M |
| 2022-23 | $67.1M | $125M |
| 2023-24 | $49.8M | $58.7M |
| 2024-25 | $50M | $67M |
| 2025-26 | $51.9M | — |
| 2026-27 | $56.2M | — |
| 2027-28 | $60.2M* | — |
| 2028-29 | $53.5M* | — |
Employees (FTEs)
Show the numbers
| Fiscal year | Planned | Actual |
|---|---|---|
| 2018-19 | 251 | 325 |
| 2019-20 | 328 | 321 |
| 2020-21 | 316 | 331 |
| 2021-22 | 369 | 398 |
| 2022-23 | 398 | 420 |
| 2023-24 | 336 | 327 |
| 2024-25 | 304 | 303 |
| 2025-26 | 296 | — |
| 2026-27 | 271 | — |
| 2027-28 | 267* | — |
| 2028-29 | 261* | — |
Planned spending, plan by plan
Each row is one year's Departmental Plan and its forecast for the next three fiscal years; read a column down to see how the forecast for one year changed. The last row is what was actually spent. Click an amount for its source. Biggest changes in federal spending plans
| Plan | 2018-19 | 2019-20 | 2020-21 | 2021-22 | 2022-23 | 2023-24 | 2024-25 | 2025-26 | 2026-27 | 2027-28 | 2028-29 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2018-19 plan | $39,737,408 | $37,856,103 | $37,986,846 | ||||||||
| 2019-20 plan | $44,356,033 | $44,486,692 | $44,486,318 | ||||||||
| 2020-21 plan | $46,364,171 | $46,792,937 | $46,909,513 | ||||||||
| 2021-22 plan | $92,186,078 | $47,706,573 | $47,695,673 | ||||||||
| 2022-23 plan | $67,058,483 | $67,051,031 | $47,571,109 | ||||||||
| 2023-24 plan | $49,840,196 | $52,251,605 | $53,316,486 | ||||||||
| 2024-25 plan | $50,010,038 | $51,297,318 | $51,808,631 | ||||||||
| 2025-26 plan | $51,873,239 | $52,392,947 | $52,425,618 | ||||||||
| 2026-27 plan | $56,207,092 | $60,243,761 | $53,483,601 | ||||||||
| Actual | $47,770,425 | $50,775,142 | $96,202,971 | $130,820,474 | $125,129,175 | $58,691,468 | $66,970,685 |
Actual spending is from Departmental Results Reports and the Public Accounts, as published in GC InfoBase. FTEs are full-time equivalents.