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Program directory · National Research Council Canada

Human Health Therapeutics

Program code
BNQ07 (NRC)
Core responsibility
Science and Innovation
In Departmental Plans
2018-19 – 2026-27 · New since an earlier plan

What it does

Through research and development of biotherapeutics, vaccines and technology platforms, the Human Health Therapeutic (HHT) program aims to transform human health outcomes for the benefit of society. HHT primarily serves the needs of small and medium enterprises (SMEs) from the Canadian biopharmaceutical industry, although it is also involved in federal government collaborative research aimed at creating solutions for public health issues affecting the lives of Canadians. HHT serves its clients and collaborators through three main mechanisms: it enters collaborative research agreements to co-develop products and technologies, it provides testing or advisory services that result in different types of information being delivered to the client, and it licenses out off-the-shelf products and technology platforms developed and owned by the program. The program directly improves the R&D and innovation capabilities of SME clients through knowledge and technology transfer while also allowing these companies to advance their biologics and vaccine pipelines by de-risking product development and manufacturing activities. HHT will soon enable the production of clinical trial material for its clients through a state of the art GMP compliant Clinical Trial Manufacturing Facility. All of this is expected to lead clients to submit for regulatory approvals, launch clinical trials and eventually commercialize novel products. HHT is ultimately expected to help Canadian biopharmaceutical companies become more competitive on the national and global stages, attract new funding and grow to scale in Canada. HHT also has a role to play in coordinating public health research efforts within the federal government so that public good solutions, such as vaccines to combat infectious diseases or therapeutics to treat rare disorders, can be developed and deployed and so that Canada is in a better position to respond to future public health crises.

Source: the department's Program Inventory, via GC InfoBase.

History and lineage

First appears in GC InfoBase's actual spending by program in 2018-19. The data does not record when a program was created; it may be older than its first appearance here, which is limited by the sources (program spending starts in 2010-11, Departmental Plans in 2018-19).

2018-192019-202020-212021-222022-232023-242024-252025-262026-272027-282028-29Human Health Therapeutics 2018-19: $47.8MHuman Health Therapeutics 2019-20: $50.8MHuman Health Therapeutics 2020-21: $96.2MHuman Health Therapeutics 2021-22: $131MHuman Health Therapeutics 2022-23: $125MHuman Health Therapeutics 2023-24: $58.7MHuman Health Therapeutics 2024-25: $67MHuman Health Therapeutics 2025-26: $51.9MHuman Health Therapeutics 2026-27: $56.2MHuman Health Therapeutics 2027-28: $60.2MHuman Health Therapeutics 2028-29: $53.5MHuman Health Therapeutics
Bars: spending by fiscal year (dark: actual; light: actual restated on the 2017-18 program structure; outlined: the latest plan's forecast; grey: related programs). Bands: each program in the lineage over the years it has data.
ProgramRelationYears with dataActual spending over those years
Human Health TherapeuticsThis program2018-19 – 2028-29$576M

No earlier or later program in the same department has a similar name.

Significant changes in scope and budget

Detected from the data: renames between plans, programs it appears to replace, merge with or split into (matched by name), year-over-year changes in spending of at least 25% and $5M, or in employees of at least 20% and 25 FTEs, linked budget measures, and results indicators added or dropped.

YearWhat changedSource
2020-21Spending $96.2M, against $50.8M in 2019-20 (+89%).Actual spending (GC InfoBase)
2021-22Employees (FTEs) 398, against 331 in 2020-21 (+20%).FTEs (GC InfoBase)
2021-22Indicators added: Citation score of Human Health Therapeutics generated publications relative to world average; Number of contractual agreements with other government departments; Number of patent applications filed; Revenue earned from all external research clientsDepartmental Results Framework (GC InfoBase)
2021-22Indicators dropped: Number of clients and collaborators working with the Research Centre annually; Number of unique intellectual assets generated by Research Centre employees; Value of external contributions to Research Centre research and development services and scientific and technological infrastructureDepartmental Results Framework (GC InfoBase)
2021-22Spending $131M, against $96.2M in 2020-21 (+36%).Actual spending (GC InfoBase)
2023-24Employees (FTEs) 327, against 420 in 2022-23 (−22%).FTEs (GC InfoBase)
2023-24Spending $58.7M, against $125M in 2022-23 (−53%).Actual spending (GC InfoBase)

Success criteria

The program's indicators from its department's Departmental Results Framework: the target set in each year's plan, and the result reported the following year. Source: GC InfoBase.

Historical: targets against results

Citation score of Human Health Therapeutics generated publications relative to world average
Expected result: Scientific & technological knowledge advances
1.222021-22✓ met1.442022-23✓ met1.252023-24✓ met1.192024-25✗ not met

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2021-22≥ 1.0520221.22Met
2022-23≥ 1.0520231.44Met
2023-24≥ 1.0520241.25Met
2024-25≥ 1.220251.19
Not required (essentially met).
Not met
Number of contractual agreements with other government departments
Expected result: Other government departments are engaged to collaborate on projects for public good innovations
112021-22✓ met82022-23✓ met52023-24✗ not met112024-25✓ met

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2021-22≥ 3202211Met
2022-23≥ 320238Met
2023-24≥ 620245
Agreements with OGDs do fluctuate from year to year and +1 or -1 is not unusual. Another agreement in development is pending.
Not met
2024-25≥ 3202511Met
Number of patent applications filed
Expected result: Scientific & technological knowledge advances
862021-22✗ not met582022-23✓ met892023-24✓ met742024-25✓ met

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2021-22≥ 100202286
HHT’s overall number of patent applications were within the expected range. First filing patent applications in any jurisdiction were up 200% in 2021-22 compared to the previous year, indicating that the results do not reflect a shortage of new inventions with commercial potential. Additionally, jurisdictions were targeted more selectively to manage escalating patent costs and some filings were d…
Not met
2022-23≥ 50202358Met
2023-24≥ 50202489Met
2024-25≥ 60202574Met
Revenue earned from all external research clients
Expected result: Industry, academia, other government departments and other research organizations use NRC research and technical expertise
$13M2021-22✓ met$16.8M2022-23✓ met$7.2M2023-24✗ not met$12.1M2024-25✓ met

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2021-22≥ $10M2022$13MMet
2022-23≥ $12M2023$16.8MMet
2023-24≥ $12M2024$7.2M
There is a fundamental shift in the business environment for many of HHT's traditional clients and partners who are struggling to find financing. HHT's outreach approach is now pivoting toward the new market directions, such as biomanufacturing and Cell and Gene Therapy (CGT), which are well-aligned with HHT's 2024-2029 Strategic Plan and expected to augment client interactions.
Not met
2024-25≥ $12M2025$12.1MMet
Number of clients and collaborators working with the Research Centre annually
Expected result: Client and collaborator investment in research and development and innovation increases through access to Research Centre expertise, services and infrastructure
1032018-19✗ not met1182019-20✓ met722020-21✗ not met

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2018-19≥ 1122019103
The number of agreements for the 2018-19 fiscal year was slightly lower than planned. In 2018-19, the Human Health and Therapeutics (HHT) program was engaged in the design and launch of the challenge program in Disruptive Technology Solutions for Cell and Gene therapy, which involved broad outreach to academic communities. It is anticipated that the resulting collaborations will be formalized in…
Not met
2019-20≥ 1002020118Met
2020-21≥ 95202172
In order to comply with public health measures associated with the COVID-19 pandemic, Human Health Therapeutics had to restrict on-site activities to focus on pandemic response priority projects, thus cancelling or postponing many projects with clients and collaborators.
Not met
Number of unique intellectual assets generated by Research Centre employees
Expected result: Scientific & technological knowledge advances
982018-19✗ not met1262019-20✓ met1112020-21✗ not met

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2018-19≥ 118201998
Peer reviewed publications were under the projected 8% growth as a result of the shift in research priorities which take more time than anticipated to generate publications. The change in our innovation strategy to focusing on larger technology bundles led to fewer disclosures. However, prior and current disclosures led to more patent filings.
Not met
2019-20≥ 1082020126Met
2020-21≥ 1162021111
Target was essentially met.
Not met
Value of external contributions to Research Centre research and development services and scientific and technological infrastructure
Expected result: Client and collaborator investment in research and development and innovation increases through access to Research Centre expertise, services and infrastructure
$12.2M2018-19✗ not met$11.7M2019-20✗ not met$8.9M2020-21✗ not met

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2018-19≥ $13M2019$12.2M
The new strategy for the Human Health and Therapeutics (HHT) program is to focus on value-added co-development with partner institutions, to build a pipeline of new Canadian therapies. As a result, in 2018-19, HHT was more selective in pursuing revenue-generating activities, resulting in less revenue generated than was originally anticipated.
Not met
2019-20≥ $12.9M2020$11.7M
In 2019-20, Human Health Therapeutics continued its shift toward public good-driven initiatives, in collaboration with other government departments and academia namely, with the Cell and Gene Therapy Challenge Program. Similarly, on the business side, the focus was more on co-development with small and medium-sized entreprises and less on service agreements. These provide more limited revenue inp…
Not met
2020-21≥ $12M2021$8.9M
In order to comply with public health measures associated with the COVID-19 pandemic, Human Health Therapeutics had to restrict on-site activities to focus on pandemic response priority projects, thus cancelling or postponing many revenue generating services normally provided.
Not met

Current: the 2026-27 plan's targets

Citation score of Human Health Therapeutics generated publications relative to world average
Expected result: Scientific & technological knowledge advances
1.22026-27

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2026-27≥ 1.22027—Planned
Number of contractual agreements with other government departments
Expected result: Other government departments are engaged to collaborate on projects for public good innovations
32026-27

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2026-27≥ 32027—Planned
Number of patent applications filed
Expected result: Scientific & technological knowledge advances
602026-27

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2026-27≥ 602027—Planned
Revenue earned from all external research clients
Expected result: Industry, academia, other government departments and other research organizations use NRC research and technical expertise
$12.4M2026-27

Bars: result reported. Dashed line: target.

Report yearTargetDueResultStatus
2026-27≥ $12.4M2027—Planned

Future goals: targets due after 2026-27

No targets with a later due date.

Spending and employees: planned against actual

Spending

2018-19: $39.7M2018-19: $47.8M2018-192019-20: $44.4M2019-20: $50.8M2019-202020-21: $46.4M2020-21: $96.2M2020-212021-22: $92.2M2021-22: $131M2021-222022-23: $67.1M2022-23: $125M2022-232023-24: $49.8M2023-24: $58.7M2023-242024-25: $50M2024-25: $67M2024-252025-26: $51.9M2025-262026-27: $56.2M2026-272027-28: $60.2M2027-282028-29: $53.5M2028-29
Outlined bar: planned in that year's Departmental Plan (dashed: the latest plan, for years not yet reported). Filled bar: actual.
Show the numbers
Fiscal yearPlannedActual
2018-19$39.7M$47.8M
2019-20$44.4M$50.8M
2020-21$46.4M$96.2M
2021-22$92.2M$131M
2022-23$67.1M$125M
2023-24$49.8M$58.7M
2024-25$50M$67M
2025-26$51.9M—
2026-27$56.2M—
2027-28$60.2M*—
2028-29$53.5M*—

Employees (FTEs)

2018-19: 2512018-19: 3252018-192019-20: 3282019-20: 3212019-202020-21: 3162020-21: 3312020-212021-22: 3692021-22: 3982021-222022-23: 3982022-23: 4202022-232023-24: 3362023-24: 3272023-242024-25: 3042024-25: 3032024-252025-26: 2962025-262026-27: 2712026-272027-28: 2672027-282028-29: 2612028-29
Outlined bar: planned in that year's Departmental Plan (dashed: the latest plan, for years not yet reported). Filled bar: actual.
Show the numbers
Fiscal yearPlannedActual
2018-19251325
2019-20328321
2020-21316331
2021-22369398
2022-23398420
2023-24336327
2024-25304303
2025-26296—
2026-27271—
2027-28267*—
2028-29261*—

Planned spending, plan by plan

Each row is one year's Departmental Plan and its forecast for the next three fiscal years; read a column down to see how the forecast for one year changed. The last row is what was actually spent. Click an amount for its source. Biggest changes in federal spending plans

Actual spending is from Departmental Results Reports and the Public Accounts, as published in GC InfoBase. FTEs are full-time equivalents.